Curated literature based database of germline human genomic variants database
NHS England · Preliminary market engagement notice on Find a Tender
✓Tender information last checkedLast checked 5 Oct 2026, 16:36.
Opportunity overview
The requirement is for a database or a tool that clinicians can use to search for rare inherited disease mutations, or search for an overview of known mutations associated with a particular disease, interpreting clinical test results, looking for the likely causal mutation in a list of variants, or seeking to integrate mutation content into your custom NGS pipeline or data repository.
The Database or tool will need to work by collating all published variants into a detailed repository of information. It should easily allow for variants to be listed using transcripts, to ensure that scientists can easily search for the variant they are researching which enormously reduces scientific analytical time, and in turn turn around times for patients.
Classification
CPV72320000 — Database services
Lots
Lot 1Value not stated
Documents and notices
Preliminary market engagement notice on Find a TenderOpen source ↗
Published notice details
Additional information from the published procurement release. Fields appear only when supplied by the source; check the original notice and tender documents before acting.
NHS England is inviting suppliers to respond to the RFI questionnaire. This is a market engagement activity and there is no guarantee that it may result in future procurement activity. Interested suppliers are invited to respond to the request for information questionnaire by the stated deadline to register their interest for this opportunity.
Due
23 Oct 2026, 23:59
Status
scheduled
Documents
Entry 1
Id
093928-2026
Document Type
marketEngagementNotice
Notice Type
UK2
Description
Preliminary market engagement notice on Find a Tender
Buyer location · London · UKI45 · SE1 8UG · United Kingdom
Notice and amendment history
1 published notice version reviewed by ProcuraAxis.
1 VERSION
1
093928-2026Preliminary market engagement notice on Find a Tender ·
PROCURAAXIS ANALYSIS
ProcuraAxis Analysis
Our approved analysis of the opportunity appears below the official tender information.
ANALYSIS PREVIEW
Opportunity intelligence at a glance
NHS England is conducting preliminary market engagement for a curated, literature-based database or tool covering germline human genomic variants. The intended solution would help clinicians and scientists search rare inherited-disease mutations, review disease-associated mutations, interpret clinical test results, identify likely causal variants, and integrate mutation content into NGS pipelines or repositories.
Who this may suit
Potential fit for suppliers of clinical genomics knowledgebases, variant-curation databases, bioinformatics software, and NGS data-integration tools. This is an early-stage planned procurement, not an open bidding opportunity.
Key points identified
Database contentCollate all published variants into a detailed information repository.Evidence: “The Database or tool will need to work by collating all published variants into a detailed repository of information.”
Search and clinical use casesSupport searching rare inherited-disease mutations, disease-associated mutation overviews, clinical test interpretation, and identification of likely causal mutations from variant lists.Evidence: The description lists these clinician use cases explicitly.
Transcript-based searchAllow variants to be listed using transcripts so scientists can readily find variants under investigation.Evidence: “It should easily allow for variants to be listed using transcripts.”
94% approved-analysis confidence5 supplier criteria identified3 risks or unknowns
ProcuraAxis structures information found in published procurement records, checks the result for consistency and publishes only approved analysis. Confidence describes the completeness and consistency of the available source information; it is not a guarantee of eligibility or contract award.
NHS England is conducting preliminary market engagement for a curated, literature-based database or tool covering germline human genomic variants. The intended solution would help clinicians and scientists search rare inherited-disease mutations, review disease-associated mutations, interpret clinical test results, identify likely causal variants, and integrate mutation content into NGS pipelines or repositories.
Who this may suit
Potential fit for suppliers of clinical genomics knowledgebases, variant-curation databases, bioinformatics software, and NGS data-integration tools. This is an early-stage planned procurement, not an open bidding opportunity.
Key deliverables
Curated repository of published germline human genomic variants
Variant and disease mutation search capability
Transcript-based variant listing and search
Support for clinical test interpretation and causal-variant investigation
Potential integration with custom NGS pipelines or data repositories
SUPPLIER REQUIREMENTS
5 criteria identified
Database content
98% confidence
Collate all published variants into a detailed information repository.
View supporting evidence
“The Database or tool will need to work by collating all published variants into a detailed repository of information.”
Search and clinical use cases
97% confidence
Support searching rare inherited-disease mutations, disease-associated mutation overviews, clinical test interpretation, and identification of likely causal mutations from variant lists.
View supporting evidence
The description lists these clinician use cases explicitly.
Transcript-based search
98% confidence
Allow variants to be listed using transcripts so scientists can readily find variants under investigation.
View supporting evidence
“It should easily allow for variants to be listed using transcripts.”
Integration capability
94% confidence
Support integration of mutation content into custom NGS pipelines or data repositories.
View supporting evidence
The requirement includes users “seeking to integrate mutation content into your custom NGS pipeline or data repository.”
Supplier eligibility requirements
99% confidence
Unknown
View supporting evidence
No supplier selection, organisation-size, geographic eligibility, or exclusion requirements are supplied.
COMMERCIAL AND DELIVERY
Contract intelligence
Commercial
Indicative total value
87% confidence
Up to GBP 2,347,766
View supporting evidence
Opportunity value_max is GBP 2,347,766; no minimum value is supplied.
Commercial model and contract term
99% confidence
Unknown
View supporting evidence
No pricing model, contract duration, payment terms, or contract dates are supplied.
Delivery
Delivery location
96% confidence
Unknown; buyer location is London (SE1 8UG), United Kingdom.
View supporting evidence
The supplied location is labelled “Buyer location”, not a delivery location.
Implementation and service levels
99% confidence
Unknown
View supporting evidence
No implementation timetable, hosting, support, service-level, or delivery requirements are supplied.
PROCEDURE
How to respond
Procurement stage
100% confidence
Preliminary market engagement / planning
View supporting evidence
Notice type is “Preliminary market engagement notice on Find a Tender”; stage and display status are planning/upcoming.
Bid status
99% confidence
Early-stage planned procurement; bidding is not stated to be open.
View supporting evidence
Display status is “upcoming” and no submission deadline is supplied.
Procurement method
100% confidence
Unknown
View supporting evidence
procurement_method and procurement_method_details are null.
Notice publication date
100% confidence
5 October 2026
View supporting evidence
published_at is 2026-10-05T15:23:42+01:00.
RISKS AND UNKNOWNS
Points requiring attention
Early-stage scope risk
99% confidence
Final scope, technical specifications, procurement route, timetable, commercial terms, and submission requirements are unknown because this is preliminary market engagement.
View supporting evidence
The opportunity is in planning/upcoming status and these fields are not supplied.
Data quality and curation risk
95% confidence
The solution is expected to collate published variants for clinical use, but no requirements are stated for curation methodology, update frequency, provenance, validation, or clinical governance.
View supporting evidence
The description requires a detailed repository of published variants but provides no quality or governance criteria.
Integration risk
96% confidence
Integration with custom NGS pipelines or repositories is referenced, but interface, format, interoperability, security, and hosting requirements are unknown.
View supporting evidence
Integration is mentioned without technical specifications.
ProcuraAxis analysis supplements, but does not replace, the original notice and tender documents. Always verify eligibility, deadlines and commercial terms with the issuing authority.
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