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PROCUREMENT OPPORTUNITY

LIONNS-D2 Project - Production of T3S API, IMP and FDF

CARDIFF UNIVERSITY · Transparency notice on Find a Tender

Tender information last checkedLast checked 30 Sept 2026, 11:31.

Opportunity overview

Cardiff University's School of Medicine is procuring the manufacture of a novel investigational medicinal product (IMP), Triiodothyronine sulphate (T3S), for use in a Phase 2b clinical trial. The service includes the production of the active pharmaceutical ingredient (API), the IMP, and the finished drug formulation (FDF) in blister packs. This bespoke drug is intended for hypothyroid patients with a specific genetic variation affecting thyroid hormone metabolism. The supplier will manufacture the product to GMP standards, using a validated Route of Synthesis supported by existing preclinical and toxicology data.

Awarded to

Amounts belong to published awards or contracts. Where several suppliers share one value, it is labelled as shared and is not a supplier-specific allocation.

Ardena Holding NV

No match
Published award value
€953.6k
Awarded
21 Oct 2025
Award ID
1
Status
pending
Identifier
GB-PPON PRMH-6467-WRPY
Location
Mariakerke, BE, 9030, Belgium

Classification

No classification was supplied.

Lots

  • Lot 1Value not stated

Documents and notices

Published notice details

Additional information from the published procurement release. Fields appear only when supplied by the source; check the original notice and tender documents before acting.

Scope, procedure and submissions

Id
CU.1623.RR
Status
complete
Procurement Method
direct
Procurement Method Details
Direct award
Why this procedure was chosen
T3S is not commercially available and must be manufactured to GMP standards using a specific Route of Synthesis (RoS) supported by existing preclinical and toxicology data. Following extensive market engagement, Ardena NV has been identified as the only supplier capable of delivering the full scope of requirements: sourcing raw materials, manufacturing the Active Pharmaceutical Ingredient (API), producing the IMP, and packaging the Finished Drug Formulation (FDF) in blister packs. Other CDMOs approached were unable to meet the technical and regulatory requirements. The direct award is justified under the following provisions of Schedule 5 of the Procurement Act 2023: - The contract concerns the supply of novel goods for research and development purposes. - Due to technical reasons and absence of competition, only one supplier can meet the requirement. - There are no reasonable alternatives available.

Legal basis

Id
2023/54
Scheme
UKPGA

Procedure reasons

Entry 1
Id
prototypesDevelopment

Lots and requirements

Entry 1
Id
1
Status
complete

Published documents

Entry 1
Id
conflictOfInterest
Description
Not published
Document Type
conflictOfInterest

Buyer, suppliers and contacts

Organisation 1
Id
GB-PPON-PHVT-4343-HWYR
Name
Cardiff University

Roles

buyer

Address

Region
UKL22
Country
GB
Locality
Cardiff
Postal Code
CF24 4HQ
Country Name
United Kingdom
Street Address
Procurement Services

Details

Classifications

Entry 1
Id
publicAuthoritySubCentralGovernment
Scheme
UK_CA_TYPE
Description
Public authority - sub-central government
Entry 2
Id
GB-WLS
Scheme
UK_CA_DEVOLVED_REGULATIONS
Description
Welsh devolved regulations apply

Identifier

Id
PHVT-4343-HWYR
Scheme
GB-PPON

Contact

Name
Jamie Jones
Organisation 2
Id
GB-PPON-PRMH-6467-WRPY
Name
Ardena Holding NV

Roles

supplier

Address

Region
BE
Country
BE
Locality
Mariakerke
Postal Code
9030
Country Name
Belgium
Street Address
Kleimoer 4

Details

Vcse
No
Scale
large
Sheltered Workshop
No
Public Service Mission Organization
No

Identifier

Id
PRMH-6467-WRPY
Scheme
GB-PPON

Contact

Organisation 3
Id
GB-COH-RC000089
Name
CARDIFF UNIVERSITY

Roles

buyer

Address

Region
UKL22
Country
GB
Locality
Cardiff
Postal Code
CF10 3AT
Country Name
United Kingdom
Street Address
Park Place

Details

Classifications

Entry 1
Id
publicAuthoritySubCentralGovernment
Scheme
UK_CA_TYPE
Description
Public authority - sub-central government
Entry 2
Id
GB-WLS
Scheme
UK_CA_DEVOLVED_REGULATIONS
Description
Welsh devolved regulations apply

Identifier

Id
RC000089
Scheme
GB-COH

Contact

Name
Jamie Jones

Additional Identifiers

Entry 1
Id
PHVT-4343-HWYR
Scheme
GB-PPON

Award information

Award 1
Id
1
Date
22 Oct 2025, 00:00
Title
LIONNS-D2 Project - Production of T3S API, IMP and FDF
Status
pending
Above Threshold
Yes
Main Procurement Category
goods

Items

Item 1
Id
1
Related Lot
1

Delivery locations

Entry 1
Region
UKL
Country
GB
Country Name
United Kingdom
Entry 2
Region
UKL
Country
GB
Country Name
United Kingdom

Additional Classifications

Entry 1
Id
33600000
Scheme
CPV
Description
Pharmaceutical products

Value

Amount
953,600
Currency
EUR
Including VAT
953,600

Documents

Entry 1
Id
067987-2025
Format
text/html
Notice Type
UK5
Description
Transparency notice on Find a Tender
Document Type
awardNotice
Published
23 Oct 2025, 17:25
Entry 2
Id
068032-2025
Format
text/html
Notice Type
UK6
Description
Contract award notice on Find a Tender
Document Type
awardNotice
Published
24 Oct 2025, 09:23

Suppliers

Supplier 1
Id
GB-PPON-PRMH-6467-WRPY
Name
Ardena Holding NV

Milestones

Entry 1
Id
1
Type
futureSignatureDate
Status
scheduled
Due
5 Nov 2025, 23:59

Related lots

1

Contract period

Ends
31 Jan 2027, 23:59
Starts
6 Nov 2025, 00:00

Standstill Period

Ends
4 Nov 2025, 23:59

Recorded locations

  • Buyer location · Cardiff · UKL22 · CF10 3AT · United Kingdom

Notice and amendment history

1 published notice version reviewed by ProcuraAxis.

1 VERSION
  1. ocds-h6vhtk-05d2df-2025-10-24T09:23:16+01:00Transparency notice on Find a Tender ·